Neurotoxicity Study of 1,3-Dichloro-2-Propanol in Rats
نویسندگان
چکیده
منابع مشابه
subchronic inhalation toxicity study of 1,3-dichloro-2-propanol in rats.
The subchronic toxicity of 1,3-dichloro-2-propanol (1,3-DCP) was investigated in Fischer 344 rats after 13 weeks of repeated, whole-body inhalation exposure. Groups of 10 rats of each sex were exposed to 1,3-DCP vapor by whole-body inhalation exposure at concentrations of 0, 5, 20 or 80 ppm for 6 h/day, 5 days/week for 13 weeks. All of the rats were sacrificed at the end of the treatment period...
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The observed toxicity and carcinogenicity of 1,3-dichloro-2-propanol (DCP) in rodents is thought to be due to the formation of reactive metabolites, epichlorohydrin (ECH) and dichloroacetone (DCA). However, there is no direct evidence for the formation of these metabolites from exposure to DCP in rodents due to the challenges of measuring these reactive intermediates directly in vivo. The objec...
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ژورنال
عنوان ژورنال: Journal of Toxicologic Pathology
سال: 2004
ISSN: 0914-9198,1881-915X
DOI: 10.1293/tox.17.37